The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin

Introduction: C-phycocyanin (C-PC), a photosynthetic protein obtained from Spirulina , is regarded highly promising commercially available biochemical. Numerous in vitro and vivo studies have provided evidence of C-PC’s ability to mitigate the inflammatory response, alleviate oxidative stress, facilitate wound healing. However, despite existing knowledge regarding protective mechanism against cellular apoptosis induced by ultraviolet B (UVB) radiation, further experiments are needed explore its anti-photoaging mechanism. Methods: In this study, UVB-induced skin photoaging model was established using BALB/c-nu mice, potential effects topically administered c-PC were investigated various molecular biology tools. addition, novel delivery system, C-PC nanodispersion, developed transdermal C-PC. Results: C- PC demonstrated significant activities skin. The application dorsal mice resulted improved macroscopic characteristics, such as reduced sagging coarse wrinkling, under UVB irradiation Histological analyses showed that treatment significantly decreased symptoms epidermal thickening, prevented dermal collagen fiber loosening, increased hydroxyproline (Hyp) content antioxidant enzymes (such superoxide dismutase, catalase, glutathione peroxidase) mouse skin, malondialdehyde levels expressions factors (interleukin-1α [IL-1α], IL-1β, IL-6, tumor necrosis factor-α), matrix metalloproteinase [MMP-3 MMP-9] expressions, inhibited phosphorylation c-Jun N-terminal kinase, extracellular signal-regulated p38 proteins mitogen-activated kinase family. Discussion: By analyzing results new drug nano-dispersion, proposed, effect investigated.